Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity. Also displays radioprotective activity, preventing apoptosis in human T-cells that were...
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Potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 µM, demonstrating the selectivity. Also displays radioprotective activity, preventing apoptosis in human T-cells that were subjected to ionizing radiation (EC50 = 3.0 – 7.6 µM)
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CHEK2 identifies checkpoint kinase 2 in Homo sapiens (Human). This target record connects NCBI Gene 11200, UniProtKB O96017 and related ABMIUM catalogue products.
