Ascochlorin is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species. It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites. It induces caspase-independent necroptosis in...
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Ascochlorin is a novel isoprenoid phenol isolated from Acremonium egyptiacum and other species. It is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory chain complex III) acting at both active sites. It induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages resulting in anti-inflammatory effects. Demonstrates substantial antineoplastic effects in a variety of tumor cell lines and mouse models
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