A retinoic acid analog acting as a RARα agonist (Kd = 8 nM). Induces or blocks differentiation depending on cell type and environment. In combination with CHIR-99021 it induces differentiation of human induced pluripotent stem cells (iPSCs) into intermediate mesoderm (80% induction rate in 5...
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A retinoic acid analog acting as a RARα agonist (Kd = 8 nM). Induces or blocks differentiation depending on cell type and environment. In combination with CHIR-99021 it induces differentiation of human induced pluripotent stem cells (iPSCs) into intermediate mesoderm (80% induction rate in 5 days) capable of forming kidney structures. AM-580 exhibits anti-angiogenic activity in vivo, and induces differentiation of acute promyelocytic leukemia cells
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