Highly potent, ATP-competitive inhibitor selective for Aurora A kinase (Ki = 0.3 nM; IC50 = 6.7 nM) over Aurora B (IC50 = 1.5 µM); does not inhibit a large panel of other kinases. Also exhibits off-target binding of GABAA (IC50 = 0.49 µM), but no effects attributable to this binding were...
Know who made it. See the evidence. Buy through one marketplace.
Highly potent, ATP-competitive inhibitor selective for Aurora A kinase (Ki = 0.3 nM; IC50 = 6.7 nM) over Aurora B (IC50 = 1.5 µM); does not inhibit a large panel of other kinases. Also exhibits off-target binding of GABAA (IC50 = 0.49 µM), but no effects attributable to this binding were observed in rats. Disrupts the Aurora A / Myc complex, resulting in Myc degradation in Myc-amplified neuroblastomas. Inhibits tumor cell growth in vitro and in vivo, causing apoptosis and autophagy, disrupted mitosis, and increased chromosome alignment abnormalities
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
