Competitive P2X7 receptor antagonist (pIC50 = 6.9). Displayed antinociceptive effects in a rat model of neuropathic pain. A-438079 prevented the LPS-induced release of IL-1ß and attenuated LPS-induced (via intrathecal lumbar injection) mechanical hyperalgesia in rat hindpaws. It prevented...
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Competitive P2X7 receptor antagonist (pIC50 = 6.9). Displayed antinociceptive effects in a rat model of neuropathic pain. A-438079 prevented the LPS-induced release of IL-1ß and attenuated LPS-induced (via intrathecal lumbar injection) mechanical hyperalgesia in rat hindpaws. It prevented mechanical hyperalgesia following peripheral nerve injury. A-438079 protected against cerebral ischemia/reperfusion injury in a rat model via reduction of the neuroinflammatory response
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