Manufactured by:TriBio Science
RUO

6-ECDCA (Obeticholic acid), FXR agonist

A novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis. Promotes adipocyte differentiation and regulates adipose cell function. A potentially new therapeutic agent for management of non-alcoholic...

SKU:
ABM146531-1
Manufacturer SKU
TBI2838-10MG | TBI2838-50MG
Product type
Biochemical Inhibitors
TargetFXR
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

A novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis. Promotes adipocyte differentiation and regulates adipose cell function. A potentially new therapeutic agent for management of non-alcoholic fatty liver disease and NASH. Displays therapeutic benefit in patients with primary biliary cirrhosis. Active in vivo

Key facts & specifications
Also known as
6-Ethylchenodeoxycholic acid; 6-ECDCA
Molecular weight
420.63
Form / buffer
Powder
Activity
A novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis. Promotes adipocyte differentiation and regulates adipose cell function. Normalizes insulin sensitivity in a rabbit model of metabolic syndrome. A potentially new therapeutic agent for management of non-alcoholic fatty liver disease and NASH. Displays therapeutic benefit in patients with primary biliary cirrhosis. Active in vivo.
Molecular formula
C 26 H 44 O 4
Solubility
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
Technical note
Stability: ≥ 1 year.
Identifiers & database references
Manufacturer SKU
TBI2838-10MG | TBI2838-50MG
CAS number
459789-99-2
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
£82.00