A novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis. Promotes adipocyte differentiation and regulates adipose cell function. A potentially new therapeutic agent for management of non-alcoholic...
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A novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis. Promotes adipocyte differentiation and regulates adipose cell function. A potentially new therapeutic agent for management of non-alcoholic fatty liver disease and NASH. Displays therapeutic benefit in patients with primary biliary cirrhosis. Active in vivo
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