NSE2 polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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function:E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,similarity:Belongs to the NSE2 family.,similarity:Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2/MMS21 and probably NSMCE1.,
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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