Fetuin-A polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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function:Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.,polymorphism:There are two common alleles, AHSG*1 and AHSG*2. AHSG*1 has Thr-248/Thr-256; AHSG*2 has Met-248/Ser-256.,similarity:Belongs to the fetuin family.,similarity:Contains 2 cystatin domains.,subunit:Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond.,tissue specificity:Synthesized in liver and selectively concentrated in bone matrix. Secrete din plasma. It is also found in dentin in much higher quantities than other plasma proteins.,
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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AHSG encodes alpha-2-HS-glycoprotein (fetuin-A), a secreted serum glycoprotein synthesized by hepatocytes and concentrated in bone matrix. The AHSG/fetuin-A target is studied in mineral handling, calcification, bone biology and metabolic or inflammatory physiology.
Biological function: Alpha-2-HS-glycoprotein (AHSG; fetuin-A) is a secreted plasma glycoprotein with calcium-binding and opsonic properties. Reviewed UniProt annotations support roles in endocytosis, influence on the mineral phase of bone and regulation of bone mineralization.
