CD8A polyclonal antibody; host Rabbit; reactivity Human, Rat, Mouse
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CD8a molecule(CD8A) Homo sapiens The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | ELISA |
|---|---|---|
| Human,Rat,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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CD8 subunit alpha (CD8A), also known as CD8 alpha and T-cell surface glycoprotein CD8 alpha chain, is a T-cell coreceptor protein. This guide connects human NCBI Gene 925, UniProtKB P01732 and ABMIUM catalogue products associated with CD8A.
Biological function: CD8 alpha is a cell-surface glycoprotein expressed on many cytotoxic T lymphocytes and functions as a coreceptor with the T-cell receptor during recognition of antigen presented by MHC class I molecules. CD8A can form alpha-alpha homodimers or alpha-beta heterodimers with CD8B.
