CD80 monoclonal antibody; host Mouse; reactivity Human
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CD80 molecule(CD80) Homo sapiens The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | IHC-P | IF/ICC | ELISA |
|---|---|---|---|
| Human |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
CD80 molecule (CD80), also known as B7-1 and T-lymphocyte activation antigen CD80, is an immunoglobulin-superfamily costimulatory molecule. This guide connects human NCBI Gene 941, UniProtKB P33681 and ABMIUM catalogue products associated with CD80.
Biological function: CD80 / B7-1 provides an important costimulatory signal for T-lymphocyte activation by acting as a ligand for CD28, augmenting MHC/T-cell receptor signalling. CD80 also binds CTLA-4, which can oppose CD28-mediated priming and limit T-cell activation, placing CD80 at a key immune costimulation and checkpoint interface.
