CA II polyclonal antibody; host Rabbit; reactivity Human, Rat
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carbonic anhydrase 2(CA2) Homo sapiens The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Rat |
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Carbonic anhydrase 2 (CA2; carbonic anhydrase II/CA-II, also CAC) is a highly active cytosolic zinc metalloenzyme that reversibly hydrates carbon dioxide. Researchers study CA2 in bicarbonate handling, intracellular pH control, renal physiology, bone biology and carbonic-anhydrase enzymology.
Biological function: CA2 catalyses the reversible interconversion of carbon dioxide and water with bicarbonate and protons. Its high catalytic efficiency supports rapid CO2/bicarbonate equilibration and acid-base homeostasis, and CA2 can participate in membrane-associated bicarbonate-transport complexes despite being primarily cytosolic.
