Beclin-1 monoclonal antibody; host Mouse; reactivity Human
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beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | Flow Cytometry | ELISA |
|---|---|---|---|---|---|
| Human |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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BECN1 (beclin 1; Beclin-1/ATG6) is a core autophagy regulator and class III PI3K-complex component linking PI3P production to autophagosome initiation and membrane trafficking.
Biological function: Beclin-1 acts as a core subunit of class III phosphatidylinositol 3-kinase complexes that generate PI3P. Distinct BECN1-containing complexes support autophagosome initiation, autophagosome maturation and endocytic trafficking, making BECN1 central to macroautophagy and membrane-remodelling pathways.
