Bak polyclonal antibody; host Rabbit; reactivity Human, Mouse
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BCL2 antagonist/killer 1(BAK1) Homo sapiens The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF/ICC | ELISA |
|---|---|---|---|---|
| Human,Mouse |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BCL2 antagonist/killer 1 (BAK1/BAK) is a pro-apoptotic BCL2-family effector located at the mitochondrial outer membrane. Following apoptotic activation, BAK changes conformation and oligomerizes to drive mitochondrial outer-membrane permeabilization. This page groups ABMIUM catalogue reagents for intrinsic-apoptosis research.
Biological function: BAK1 is a mitochondrial apoptosis effector. Pro-apoptotic activation promotes BAK conformational change and homo-oligomerization in the outer mitochondrial membrane, increasing membrane permeability and enabling release of cytochrome c and other apoptogenic factors that support downstream caspase activation.
