ATG3 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB |
|---|---|
| Human,Mouse,Rat |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
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ATG3 encodes an E2-like conjugating enzyme required for lipidation of ATG8-family proteins during autophagosome formation. This target record connects reviewed human ATG3 identifiers with ABMIUM catalogue products targeting ATG3.
Biological function: ATG3 is an E2 conjugating enzyme in the autophagy machinery. It catalyses covalent conjugation of ATG8-family proteins, including LC3 and GABARAP family members, to phosphatidylethanolamine-containing membrane lipids. ATG3 cycles between ATG7-mediated loading and the ATG12-ATG5-ATG16L1 E3-like complex to promote ATG8 lipidation and formation of autophagic isolation membranes.
