ALDH1A2 polyclonal antibody; host Rabbit; reactivity Human, Mouse, Rat
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aldehyde dehydrogenase 1 family member A2(ALDH1A2) Homo sapiens This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human,Mouse,Rat |
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ALDH1A2 (aldehyde dehydrogenase 1 family member A2), commonly called retinal dehydrogenase 2 or RALDH2, is a retinaldehyde dehydrogenase that generates retinoic acid, a vitamin A-derived signalling molecule. Researchers study ALDH1A2 to examine spatial control of retinoid signalling, developmental patterning and tissue-specific retinoic acid metabolism.
Biological function: ALDH1A2 catalyses NAD-dependent oxidation of retinaldehyde to retinoic acid, providing a key biosynthetic step that controls local retinoic acid availability. Retinal dehydrogenase 2 therefore contributes to retinoid-dependent transcriptional programmes in developing and adult tissues.
