ALDH1A1 monoclonal antibody; host Mouse; reactivity Human
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aldehyde dehydrogenase 1 family member A1(ALDH1A1) Homo sapiens The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011],
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species / reactivity | WB | IHC-P | IF | ELISA |
|---|---|---|---|---|
| Human |
This product is manufactured by Reed Biotech and sold through ABMIUM without relabelling.
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ALDH1A1 encodes aldehyde dehydrogenase 1 family member A1, the reviewed human protein aldehyde dehydrogenase 1A1. This cytosolic NAD-dependent enzyme oxidizes a broad range of aldehydes and also converts retinaldehyde to retinoic acid, linking aldehyde metabolism with vitamin A/retinoid biology.
Biological function: ALDH1A1 catalyses the irreversible oxidation of aldehydes to their corresponding carboxylic acids. Reviewed UniProt supports a role downstream of retinol dehydrogenases in converting retinaldehyde to retinoic acid, the second oxidation step from retinol/vitamin A to retinoic acid.
