Manufactured by:Promab
RUO

Anti-LARGE Rabbit Polyclonal Antibody

LARGE antibody from Promab.

SKU:
ABM416673-1
Product type
Primary antibodies
TargetLARGE
ApplicationsWB, Flow Cytometry
Species / reactivityHuman, Mouse

Manufacturer provenance

Manufactured by:
Promab
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer.

For research use only.

Key facts & specifications
Also known as
Glycosyltransferase-like protein LARGE1; 2.4.-.-; Acetylglucosaminyltransferase-like 1A; Xylosyltransferase LARGE; 2.4.2.-; Beta-1; 3-glucuronyltransferase LARGE; 2.4.1.-; LARGE; KIAA0609; LARGE1; LARGE xylosyl- and glucuronyltransferase 1; Xylosyl- and glucuronyltransferase LARGE1
Host species
Rabbit
Clonality
Polyclonal
Conjugation
Unconjugated
Immunogen
This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.
Molecular weight
88.1 kDa
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application matrix

Evidence status by application and model.

SpeciesWBIHCIHC-PIHC-FIF/ICCFlow CytometryELISAIPChIP
Human
Mouse
Identifiers & database references
Gene symbol
LARGE1
Gene ID
9215
UniProt accession
O95461
Ensembl
ENSG00000133424
HGNC
6511
OMIM
603590
Storage, stability & shipping
Short-term storage
4°C (short term)
Long-term storage
-20°C (long term); aliquot and avoid repeated freeze-thaw cycles
Aliquoting guidance
Aliquot to avoid repeated freeze-thaw.
Compliance & documents
CE marked
No
Frequently asked questions
Who manufactured this product?

This product is manufactured by Promab and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

Promab
£174.20