HER3 antibody from Promab.
Know who made it. See the evidence. Buy through one marketplace.
Tyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation. ERBB3 functions primarily as a heterodimer, preferentially partnering with ERBB2/HER2, which phosphorylates ERBB3 on specific tyrosine residues and provides the kinase activity required for downstream signalling. ERBB3 binds neuregulins NRG1 and NRG2 through its extracellular domain, which induces conformational change from a tethered autoinhibited state to an extended conformation competent for dimerization.
For research use only.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IHC-P | IHC-F | IF/ICC | Flow Cytometry | ELISA | IP | ChIP |
|---|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by Promab and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Erb-b2 receptor tyrosine kinase 3 (ERBB3), also known as HER3, is an EGFR-family receptor that forms signalling heterodimers with other ERBB receptors. ABMIUM catalogue products linked below support research on ERBB3/HER3 biology.
Biological function: Erb-b2 receptor tyrosine kinase 3 (ERBB3/HER3) is an EGFR-family transmembrane receptor with impaired intrinsic kinase activity that signals through heterodimerisation with other ERBB receptors. Ligands including neuregulins promote receptor complex formation and downstream pathways such as PI3K-AKT, supporting cell growth, survival and differentiation.
