Utomilumab Biosimilar – Anti-Human TNFRSF9 mAb – Research Grade from ProteoGenix; catalogue PX-TA1012; research use only.
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Utomilumab is a monoclonal antibody that binds to 4-IBB protein (also known as CD137 protein). 4-IBB protein is a receptor found in different immune cells such as helper T-cells, killer T-cells and natural killer cells. 4-IBB/CD137 protein is a costimulatory receptor whose activation results in a series of events that leads to cytokine secretion and effector functions. Hence, targeting CD137 protein has been linked to antitumor immunity response and overall tumor reduction. Indeed, once utomilumab is injected in the bloodstream its specific binding to CD137 protein stimulates the immune cells which, as a result, enhances the immune response against tumors.
Utomilumab is under investigation as a potential treatment for advanced forms of cancer either alone or in combination with other therapies. Indeed, pre-clinical studies have suggested that the combination of utomilumab with a checkpoint inhibitor such as anti-PD1/anti-PDL1, or other immunotherapies may lead to amplified immune response. This demonstrates utomilumab anti-tumor activity.
Phase 1 study evaluated the outcome of administering utomilumab in combination with rituximab in patients with certain type of non-Hodgkin’s lymphoma (NHL) also known as CD20-positive NHL. Phase I clinical trial results further confirmed the anti-tumor activity of utomilumab. The utomilumab administration with rituximab was well tolerated and none of the patients interrupted the treatment because of treatment-related side effects. No dose-related toxicities were recorded. The safety and anti-tumor activity of this antibody-based therapy was assessed in phase 1b clinical trial. Utomilumab was tested in combination with pembrolizumab for different advanced solid tumors including renal cell carcinoma, head and neck cancer, thyroid cancer, pancreatic cancer, non-small cell lung cancer, small cell lung cancer, colon cancer, sarcoma, thymoma and melanoma. Result showed that the administration of utomilumab together with pembrolizumab to patients with solid tumors was safe. Once again, no toxicity was observed with increased doses of utomilumab. This product is for research use only.
ProteoGenix catalogue number PX-TA1012.
Target: Utomilumab Biosimilar – Anti-Human TNFRSF9 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: Mammalian cells; Purity: >85%; Molecular weight: LC: 24kDa HC: 51kDa; Buffer: PBS pH7.5; Reactivity: Human; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg, 10mg, 25mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Human |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
