Manfidokimab Biosimilar – Anti-IL-4 receptor subunit alpha mAb – Research Grade from ProteoGenix; catalogue PX-TA1788; research use only.
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The development of monoclonal antibodies (mAbs) has revolutionized the field of medicine, providing targeted and effective treatments for a variety of diseases. One such mAb, Manfidokimab Biosimilar, is a promising therapeutic option for a range of inflammatory and autoimmune conditions. In this article, we will delve into the structure, activity, and potential applications of this novel mAb.
Manfidokimab Biosimilar, also known as anti-IL-4 receptor subunit alpha mAb, is a monoclonal antibody that targets the IL-4 receptor, a key player in the inflammatory response. It is a recombinant, humanized IgG1 antibody, meaning that it is derived from human antibodies and has been modified to reduce immunogenicity. The antibody has a molecular weight of approximately 150 kDa and consists of two heavy chains and two light chains, connected by disulfide bonds.
The variable region of Manfidokimab Biosimilar is responsible for its specificity and binding affinity to the IL-4 receptor. This region is composed of six complementarity-determining regions (CDRs), which interact with the target receptor. The constant region of the antibody is responsible for its effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).
The IL-4 receptor is expressed on the surface of various immune cells, including T cells, B cells, and macrophages. It plays a crucial role in the regulation of immune responses, particularly in the development of T helper 2 (Th2) cells and the production of pro-inflammatory cytokines. Dysregulation of the IL-4 receptor signaling has been implicated in the pathogenesis of several inflammatory and autoimmune diseases, making it an attractive therapeutic target.
Manfidokimab Biosimilar binds to the IL-4 receptor with high affinity, preventing the binding of IL-4 and IL-13, two key cytokines involved in Th2 cell differentiation and inflammation. This blockade of the IL-4 receptor signaling pathway leads to a reduction in cytokine production and subsequent suppression of the inflammatory response. In addition, the antibody’s effector functions can contribute to the elimination of IL-4 receptor-expressing cells, further reducing inflammation.
Manfidokimab Biosimilar is currently being investigated for its potential use in a variety of inflammatory and autoimmune conditions, including atopic dermatitis, asthma, and rheumatoid arthritis. In preclinical studies, the antibody has shown promising results in reducing disease severity and improving clinical outcomes.
In a phase II clinical trial for moderate-to-severe atopic dermatitis, patients treated with Manfidokimab Biosimilar showed significant improvements in their skin lesions compared to placebo. The antibody has also shown efficacy in reducing asthma exacerbations in patients with severe, uncontrolled asthma. In addition, Manfidokimab Biosimilar has demonstrated potential for the treatment of rheumatoid arthritis, with a phase II study showing a significant reduction in disease activity scores in patients treated with the antibody.
Furthermore, the use of Manfidokimab Biosimilar as a research grade antibody has also been explored. Its high specificity and potency make it a valuable tool for studying the IL-4 receptor signaling pathway and its role in various diseases.
In summary, Manfidokimab Biosimilar is a novel anti-IL-4 receptor subunit alpha mAb with a unique structure and potent activity against the IL-4 receptor. Its potential applications in various inflammatory and autoimmune diseases make it a promising therapeutic option. Further clinical trials will help determine the full extent of its efficacy and safety, potentially
ProteoGenix catalogue number PX-TA1788. For research use only.
Target: Manfidokimab Biosimilar – Anti-IL-4 receptor subunit alpha mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Buffer: PBS buffer PH7.5; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Manfidokimab Biosimilar – Anti-IL-4 receptor subunit alpha mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
