Luveltamab Biosimilar – Anti-FOLR1 mAb – Research Grade from ProteoGenix; catalogue PX-TA1862; research use only.
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Luveltamab Biosimilar, also known as Anti-FOLR1 mAb, is a novel monoclonal antibody that has been developed as a biosimilar to the therapeutic antibody Farletuzumab. It is a highly specific antibody that targets the folate receptor alpha (FOLR1), a protein that is overexpressed in many types of cancer cells. Luveltamab Biosimilar has shown promising results in preclinical studies and is currently being evaluated in clinical trials as a potential treatment for various types of cancer.
Luveltamab Biosimilar is a recombinant humanized monoclonal antibody that is composed of two identical heavy chains and two identical light chains. The heavy chains consist of a constant region and a variable region, while the light chains consist of a constant region and a variable region. The variable regions of both the heavy and light chains are responsible for binding to the FOLR1 protein.
The constant regions of Luveltamab Biosimilar are derived from human antibodies, making it less likely to cause an immune response in patients. This is an important factor in the development of biosimilars, as they must demonstrate similar efficacy and safety profiles to the original therapeutic antibody.
Luveltamab Biosimilar works by binding to the FOLR1 protein on the surface of cancer cells. This binding triggers a series of events that ultimately leads to the death of the cancer cell. One of the main mechanisms of action of Luveltamab Biosimilar is antibody-dependent cellular cytotoxicity (ADCC), where the antibody binds to the cancer cell and activates immune cells, such as natural killer cells, to attack and kill the cancer cell.
In addition to ADCC, Luveltamab Biosimilar also inhibits the growth and proliferation of cancer cells by blocking the interaction between FOLR1 and its ligands, such as folate and vitamin B9. This prevents the cancer cells from obtaining essential nutrients for their survival and growth.
Luveltamab Biosimilar is being developed as a potential treatment for various types of cancer, including ovarian, lung, breast, and endometrial cancer. These cancers are known to overexpress FOLR1, making it an ideal therapeutic target for Luveltamab Biosimilar.
In preclinical studies, Luveltamab Biosimilar has shown promising results in inhibiting the growth and proliferation of cancer cells, as well as inducing cell death. It has also demonstrated a good safety profile, with no significant adverse effects observed.
Luveltamab Biosimilar is currently being evaluated in a phase I clinical trial for the treatment of advanced solid tumors. The primary objective of this trial is to assess the safety and tolerability of Luveltamab Biosimilar in patients, as well as to determine the recommended dose for future studies.
In addition, Luveltamab Biosimilar is also being evaluated in combination with other cancer therapies, such as chemotherapy and immune checkpoint inhibitors, in clinical trials for various types of cancer. These trials aim to assess the efficacy of Luveltamab Biosimilar in combination with other treatments and to determine its potential as a first-line or second-line therapy.
Luveltamab Biosimilar is a promising novel monoclonal antibody that targets the FOLR1 protein, which is overexpressed in many types of cancer cells. Its unique mechanism of action, through both ADCC and inhibition of FOLR1 signaling, makes it a potential treatment option for various types of cancer. With ongoing clinical trials, Luveltamab Biosimilar has the potential to provide a safe and effective treatment option for patients with cancer.
ProteoGenix catalogue number PX-TA1862. For research use only.
Target: Luveltamab Biosimilar – Anti-FOLR1 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Buffer: PBS buffer PH7.5; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Luveltamab Biosimilar – Anti-FOLR1 mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
