Ifinatamab Biosimilar – Anti-CD276 mAb – Research Grade from ProteoGenix; catalogue PX-TA1847; research use only.
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Ifinatamab Biosimilar, also known as Anti-CD276 mAb, is a research grade monoclonal antibody that has shown promising results in the treatment of various cancers. This antibody specifically targets the CD276 protein, which is overexpressed in many types of cancer cells. In this article, we will delve into the structure, activity, and potential applications of Ifinatamab Biosimilar.
Ifinatamab Biosimilar is a monoclonal antibody, meaning it is derived from a single type of immune cell. It is a fully humanized antibody, meaning it is made up of human proteins and is less likely to cause an immune response in patients. The antibody is composed of two identical heavy chains and two identical light chains, which are connected by disulfide bonds. These chains form the Y-shaped structure commonly seen in antibodies.
The variable regions of Ifinatamab Biosimilar are responsible for its specificity towards the CD276 protein. These regions, also known as the antigen-binding regions, are located at the tips of the Y-shaped structure and are highly variable between different antibodies. The constant regions of the antibody are responsible for its effector functions, such as binding to immune cells and activating them to attack cancer cells.
The primary activity of Ifinatamab Biosimilar is its ability to bind to the CD276 protein. CD276, also known as B7-H3, is a cell surface protein that is overexpressed in many types of cancer cells. This protein plays a role in promoting cancer cell growth and survival, making it an attractive target for cancer treatment.
When Ifinatamab Biosimilar binds to CD276, it blocks its activity and prevents it from promoting cancer cell growth. This can lead to the death of cancer cells and inhibit tumor growth. Additionally, the binding of Ifinatamab Biosimilar to CD276 can also activate the immune system to attack cancer cells, further enhancing its anti- cancer activity.
The primary application of Ifinatamab Biosimilar is in the treatment of cancer. It has shown promising results in preclinical studies and is currently being evaluated in clinical trials for various types of cancer, including lung cancer, breast cancer, and ovarian cancer. The ability of Ifinatamab Biosimilar to specifically target CD276 makes it a potentially effective and safe treatment option for these cancers.
Furthermore, Ifinatamab Biosimilar may also have potential applications in immunotherapy. By activating the immune system to attack cancer cells, it can be used in combination with other immunotherapies to enhance their efficacy. This could potentially lead to more effective and personalized treatments for cancer patients.
Ifinatamab Biosimilar, also known as Anti-CD276 mAb, is a research grade monoclonal antibody that specifically targets the CD276 protein. Its structure, activity, and potential applications make it a promising candidate for the treatment of various types of cancer. As research and clinical trials continue, Ifinatamab Biosimilar may play a crucial role in improving outcomes for cancer patients and advancing the field of cancer treatment.
ProteoGenix catalogue number PX-TA1847. For research use only.
Target: Ifinatamab Biosimilar – Anti-CD276 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Buffer: PBS buffer PH7.5; Applications: WB, ELISA, Flow Cyt.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Ifinatamab Biosimilar – Anti-CD276 mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
