EGFR / ERBB1 / HER1, C-His, recombinant protein from ProteoGenix; catalogue PX-P5701; research use only.
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EGFR (Epidermal Growth Factor Receptor, also known as ERBB1 or HER1) is a transmembrane receptor tyrosine kinase, composed of an extracellular ligand binding domain, a transmembrane region and an intracellular tyrosine kinase domain.
ActivityEGFR is activated by binding of its ligand, epidermal growth factor (EGF). This binding causes a conformational change in the receptor, leading to autophosphorylation of its tyrosine kinase domain and the initiation of downstream signaling pathways.
ApplicationEGFR is involved in a variety of cellular processes, including cell proliferation, differentiation, and migration. It is also a target for antibody-drug conjugates, which are used in the treatment of various cancers.
ProteoGenix catalogue number PX-P5701. For research use only.
Host: Mammalian cells; Expression system: Eukaryotic expression; Purity: >90% as determined by SDS-PAGE; Molecular weight: 134.29 kDa; Tag: C-terminal His Tag; Fragment: Met1-Ser645; Buffer: PBS, pH7.5; Applications: ELISA, WB.
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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