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Ebribafusp Biosimilar – Anti-C3 fusion protein – Research Grade

Ebribafusp Biosimilar – Anti-C3 fusion protein – Research Grade from ProteoGenix; catalogue PX-TA2225; research use only.

SKU:
ABM133896-1
Manufacturer SKU
PX-TA2225
Product type
Primary Antibodies
TargetEbribafusp Biosimilar – Anti-C3 fusion protein – Research Grade
Expression systemXtenCHO
Purity>95% by SDS-PAGE

Manufacturer provenance

Manufactured by:
ProteoGenix
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Introduction to Ebribafusp Biosimilar

Ebribafusp Biosimilar, also known as Anti-C3 fusion protein, is a therapeutic protein that has been designed to target the complement system, specifically the C3 protein. This biosimilar is a research grade compound that has shown promising results in pre-clinical studies and is currently undergoing clinical trials for various medical conditions. In this article, we will discuss the structure, activity, and potential applications of Ebribafusp Biosimilar.

Structure of Ebribafusp Biosimilar

Ebribafusp Biosimilar is a fusion protein that consists of two components: a humanized antibody fragment and a C3 inhibitor. The antibody fragment is derived from a human monoclonal antibody and has been modified to specifically target the C3 protein. The C3 inhibitor is a small molecule that binds to the C3 protein and prevents its activation. The fusion of these two components results in a potent therapeutic protein that can effectively inhibit the complement system.

The structure of Ebribafusp Biosimilar is similar to that of the natural C3 protein, allowing it to bind to the same receptors and exert its inhibitory effects. This makes it an ideal therapeutic agent for targeting the complement system without causing any adverse immune reactions.

Activity of Ebribafusp Biosimilar

Ebribafusp Biosimilar works by inhibiting the activity of the C3 protein, which is a key component of the complement system. The complement system is a part of the immune system that helps in fighting off infections and clearing damaged cells. However, in certain medical conditions, the complement system can become overactive and cause damage to healthy cells and tissues. This is where Ebribafusp Biosimilar comes in.

By targeting the C3 protein, Ebribafusp Biosimilar prevents it from being activated and triggering the complement cascade. This helps in reducing inflammation, tissue damage, and other harmful effects caused by an overactive complement system. Additionally, Ebribafusp Biosimilar has also been shown to have immunomodulatory effects, which further enhances its therapeutic potential.

Potential Applications of Ebribafusp Biosimilar

Ebribafusp Biosimilar has shown promising results in pre-clinical studies and is currently being evaluated in clinical trials for various medical conditions. Some of the potential applications of this therapeutic protein include:

  • Autoimmune Diseases: Ebribafusp Biosimilar has shown potential in treating autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. By inhibiting the complement system, it can help in reducing inflammation and tissue damage associated with these conditions.
  • Inflammatory Disorders: Inflammation plays a major role in various medical conditions, and Ebribafusp Biosimilar has shown to be effective in reducing inflammation. This makes it a potential treatment option for disorders such as inflammatory bowel disease, psoriasis, and asthma.
  • Transplant Rejection: The complement system can also play a role in organ transplant rejection. Ebribafusp Biosimilar has shown to be effective in preventing this by inhibiting the complement system and reducing tissue damage.
  • Other Medical Conditions: Ebribafusp Biosimilar is also being evaluated for its potential in treating other medical conditions such as age-related macular degeneration, diabetic nephropathy, and certain types of cancer.

Conclusion

Ebribafusp Biosimilar, also known as Anti-C3 fusion protein, is a promising therapeutic protein that has shown potential in targeting the complement system. Its unique structure, potent activity, and potential applications make it a valuable addition to the field of therapeutic proteins. With ongoing clinical trials, we can expect to see more promising results and potential uses for this biosimilar in the near future.

ProteoGenix catalogue number PX-TA2225. For research use only.

Target: Ebribafusp Biosimilar – Anti-C3 fusion protein – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: >95% by SDS-PAGE; Buffer: 0.01M PBS, pH 7.4.

Available configurations: 50ug, 100ug, 1mg.

Download the manufacturer datasheet

Key facts & specifications
Also known as
anti-C3, ASP, Complement C3, C3adesArg, C3bc, CPAMD1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement factor H, CFH, H factor 1, HF1, HF, HF2
Clonality
Monoclonal
Isotype
Chimeric IgG4-kappa anti-(human complement C3d) fused at the C-terminus of the heavy chain, via a (G4S)2 peptide linker to human complement factor H fragment.
Source organism
Human
Sequence
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
Technical note
For research use only. Not suitable for human use.
Identifiers & database references
Manufacturer SKU
PX-TA2225
UniProt accession
P01024 & P08603
Storage, stability & shipping
Storage conditions
4°C for short term; -20°C for long term
Shipped at
Blue ice (+4°C)
Compliance & documents
ISO certifications
ISO 9001:2023, ISO 14001: 2023
Datasheet
Open datasheet
Frequently asked questions
Who manufactured this product?

This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

ProteoGenix
£145.00£116.00