Calpurbatug Biosimilar – Anti-DNA-binding protein HU-alpha mAb – Research Grade from ProteoGenix; catalogue PX-TA2054; research use only.
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Calpurbatug Biosimilar – Anti-DNA-binding protein HU-alpha mAb – Research Grade is a novel therapeutic antibody that has been developed as a biosimilar to the anti-DNA-binding protein HU-alpha monoclonal antibody (mAb). This biosimilar has been designed to mimic the structure and function of the original anti-DNA-binding protein HU-alpha mAb, while also providing improved efficacy and safety profiles. In this article, we will explore the structure, activity, and potential applications of Calpurbatug Biosimilar in the field of antibody-based therapeutics.
Calpurbatug Biosimilar is a monoclonal antibody that is produced through recombinant DNA technology. It is composed of two identical heavy chains and two identical light chains, each with a molecular weight of approximately 150 kDa. The heavy and light chains are connected by disulfide bonds to form a Y-shaped structure, with the antigen-binding regions located at the tips of the Y. The antigen-binding regions are highly specific and recognize the target protein, DNA-binding protein HU-alpha.
The primary activity of Calpurbatug Biosimilar is to bind to the DNA-binding protein HU-alpha with high affinity and specificity. This binding prevents the interaction of HU-alpha with DNA, thereby inhibiting its function. HU-alpha is a critical protein involved in DNA replication, transcription, and repair, and its dysregulation has been linked to various diseases, including cancer and autoimmune disorders. By blocking the activity of HU-alpha, Calpurbatug Biosimilar has the potential to modulate these disease processes and provide therapeutic benefits.
In addition to its primary activity, Calpurbatug Biosimilar also possesses several secondary activities that contribute to its therapeutic potential. These include antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent cellular phagocytosis (ADCP). These mechanisms of action involve the recruitment and activation of immune cells, leading to the destruction of cells expressing HU-alpha, such as cancer cells or cells involved in autoimmune responses.
Calpurbatug Biosimilar has a wide range of potential applications in the field of antibody-based therapeutics. Its primary target, the DNA-binding protein HU-alpha, is overexpressed in various cancers, including breast, lung, and prostate cancer. By inhibiting the activity of HU-alpha, Calpurbatug Biosimilar has the potential to slow down or stop the growth of cancer cells, making it a promising candidate for cancer therapy.
Moreover, HU-alpha has also been implicated in autoimmune disorders, such as systemic lupus erythematosus and rheumatoid arthritis. By blocking the activity of HU-alpha, Calpurbatug Biosimilar may help to alleviate the symptoms of these diseases and provide relief to patients.
In addition to cancer and autoimmune disorders, Calpurbatug Biosimilar may also have potential applications in the field of infectious diseases. HU-alpha has been shown to play a role in the replication of viruses, such as HIV and hepatitis B, and its inhibition by Calpurbatug Biosimilar may help to control viral infections.
In summary, Calpurbatug Biosimilar – Anti-DNA-binding protein HU-alpha mAb – Research Grade is a novel therapeutic antibody with a specific structure and activity aimed at targeting the DNA-binding protein HU-alpha. Its potential applications in cancer, autoimmune disorders, and infectious diseases make it a promising candidate for further research and development. With its improved efficacy and safety profiles, Calpurbatug Biosimilar may offer a more effective and safer treatment option for patients in the future.
ProteoGenix catalogue number PX-TA2054. For research use only.
Target: Calpurbatug Biosimilar – Anti-DNA-binding protein HU-alpha mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: >90% by SDS-PAGE.; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA, WB.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Calpurbatug Biosimilar – Anti-DNA-binding protein HU-alpha mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
