Bemiltenase Alfa Biosimilar – Anti-Coagulation factor X-activating enzyme heavy chain mAb – Research Grade from ProteoGenix; catalogue PX-TA2153; rese
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Introduction to Bemiltenase Alfa Biosimilar – A Novel Anti-Coagulation Factor X-Activating Enzyme Heavy Chain mAb Bemiltenase Alfa Biosimilar, also known as Anti-Coagulation Factor X-Activating Enzyme Heavy Chain monoclonal antibody (mAb), is a promising therapeutic agent that has gained significant attention in the field of anti-coagulation therapy. This biosimilar is a recombinant protein produced through advanced biotechnology processes, and is designed to target and inhibit the activity of Factor X, a key factor involved in the coagulation cascade. In this article, we will explore the structure, activity, and potential applications of Bemiltenase Alfa Biosimilar in detail.
Bemiltenase Alfa Biosimilar is a recombinant monoclonal antibody that is produced by genetically engineering Chinese hamster ovary (CHO) cells. The antibody has a molecular weight of approximately 150 kDa and is composed of two heavy chains and two light chains. The heavy chains are linked together by disulfide bonds and form the antigen-binding fragment (Fab) region, which is responsible for binding to its target, Factor X. The light chains, on the other hand, are responsible for stabilizing the structure of the antibody.
Bemiltenase Alfa Biosimilar exerts its therapeutic effect by specifically targeting and binding to Factor X, a key enzyme involved in the coagulation cascade. Once bound, the antibody inhibits the activity of Factor X, thereby preventing the formation of thrombin, a crucial step in the coagulation process. This ultimately leads to a reduction in blood clot formation and helps prevent the risk of thrombotic events, such as stroke and myocardial infarction.
Bemiltenase Alfa Biosimilar has shown promising results in preclinical studies and is currently being evaluated in clinical trials for its potential therapeutic applications. The primary use of this biosimilar is in the treatment and prevention of thrombotic disorders, such as deep vein thrombosis, pulmonary embolism, and atrial fibrillation. Additionally, Bemiltenase Alfa Biosimilar may also have potential applications in the management of bleeding disorders, such as hemophilia A and B, where it can be used as an adjunct to standard therapy.
Compared to existing anti-coagulation therapies, Bemiltenase Alfa Biosimilar offers several advantages. Firstly, as a biosimilar, it is a more affordable alternative to the expensive originator antibody. Additionally, Bemiltenase Alfa Biosimilar has a longer half-life, allowing for less frequent dosing and potentially improving patient adherence. Furthermore, the targeted mechanism of action of this biosimilar may result in a lower risk of bleeding complications compared to traditional anti-coagulation therapies.
In conclusion, Bemiltenase Alfa Biosimilar is a novel therapeutic agent that has shown promising results in preclinical studies and is currently being evaluated in clinical trials. Its unique structure and mechanism of action make it a potential game-changer in the field of anti-coagulation therapy. With its potential to improve patient outcomes and reduce healthcare costs, Bemiltenase Alfa Biosimilar has the potential to become a valuable addition to the arsenal of anti-coagulation therapies.
ProteoGenix catalogue number PX-TA2153. For research use only.
Target: Bemiltenase Alfa Biosimilar – Anti-Coagulation factor X-activating enzyme heavy chain mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: >95% by SDS-PAGE.; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA.
Available configurations: 50ug, 100ug, 1mg.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Target | WB | IHC-P | IHC-Fr | IF/ICC | Flow Cyt | IP | ChIP | ELISA |
|---|---|---|---|---|---|---|---|---|
| Bemiltenase Alfa Biosimilar – Anti-Coagulation factor X-activating enzyme heavy chain mAb – Research Grade |
This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
