Aplitabart Biosimilar – Anti-TRAILR2 mAb – Research Grade

Title: Introduction to Aplitabart Biosimilar – Anti-TRAILR2 mAb

Aplitabart Biosimilar – Anti-TRAILR2 mAb is a therapeutic antibody that targets the tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAILR2), also known as death receptor 5 (DR5). This biosimilar is a research grade product that has shown promising results in pre-clinical studies and is currently being evaluated for its potential use in cancer therapy.

Structure of Aplitabart Biosimilar – Anti-TRAILR2 mAb

Aplitabart Biosimilar – Anti-TRAILR2 mAb is a monoclonal antibody that is designed to mimic the structure and function of the original therapeutic antibody, Aplitabart, which is a fully humanized antibody. It is composed of two identical heavy chains and two identical light chains, which are held together by disulfide bonds. The antibody has a molecular weight of approximately 150 kDa and is produced using recombinant DNA technology in mammalian cells.

Activity of Aplitabart Biosimilar – Anti-TRAILR2 mAb

The main activity of Aplitabart Biosimilar – Anti-TRAILR2 mAb is its ability to bind to and block the TRAILR2 receptor. This receptor is found on the surface of cancer cells and is responsible for inducing apoptosis, or programmed cell death, in these cells. By binding to TRAILR2, Aplitabart Biosimilar – Anti-TRAILR2 mAb prevents the receptor from triggering apoptosis, thereby promoting cancer cell survival and growth.

In addition to blocking TRAILR2, Aplitabart Biosimilar – Anti-TRAILR2 mAb also has the ability to activate the immune system’s natural killer (NK) cells. These cells are responsible for identifying and destroying cancer cells. By activating NK cells, Aplitabart Biosimilar – Anti-TRAILR2 mAb enhances the body’s own immune response against cancer cells, making it a promising therapeutic option for cancer treatment.

Application of Aplitabart Biosimilar – Anti-TRAILR2 mAb

Aplitabart Biosimilar – Anti-TRAILR2 mAb is currently being evaluated for its potential use in cancer therapy. Pre-clinical studies have shown that this biosimilar is effective in inhibiting the growth of various types of cancer cells, including breast, lung, and colon cancer. It has also shown promising results in combination with other cancer treatments, such as chemotherapy and radiation therapy.

One of the major advantages of Aplitabart Biosimilar – Anti-TRAILR2 mAb is its specificity for cancer cells. Unlike traditional chemotherapy, which can also harm healthy cells, Aplitabart Biosimilar – Anti-TRAILR2 mAb specifically targets cancer cells, minimizing side effects and improving treatment outcomes.

In addition to its potential use in cancer therapy, Aplitabart Biosimilar – Anti-TRAILR2 mAb may also have applications in other diseases where TRAILR2 is involved, such as autoimmune disorders and inflammatory diseases. Further research is needed to explore these potential applications.

Conclusion

Aplitabart Biosimilar – Anti-TRAILR2 mAb is a promising therapeutic antibody that targets the TRAILR2 receptor found on cancer cells. Its ability to block TRAILR2 and activate NK cells makes it a potential treatment option for various types of cancer. With its specificity for cancer cells and potential applications in other diseases, Aplitabart Biosimilar – Anti-TRAILR2 mAb has the potential to improve cancer treatment outcomes and benefit patients in need.

ProteoGenix catalogue number PX-TA2170. For research use only.

Target: Aplitabart Biosimilar – Anti-TRAILR2 mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: >95% by SDS-PAGE; Buffer: 0.01M PBS, pH 7.4; Applications: ELISA.

Available configurations: 50ug, 100ug, 1mg.

Download the manufacturer datasheet