Manufactured by:ProteoGenix
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Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade

Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade from ProteoGenix; catalogue PX-TA2044; research use only.

SKU:
ABM134019-1
Manufacturer SKU
PX-TA2044
Product type
Primary Antibodies
TargetAnzurstobart Biosimilar – Anti-BIT mAb – Research Grade
ApplicationsELISA, WB
Expression systemXtenCHO
Purity>90% by SDS-PAGE.

Manufacturer provenance

Manufactured by:
ProteoGenix
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade Introduction

Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade is a novel biosimilar antibody that targets the therapeutic protein BIT (Biosimilar Inhibitor of Tumorigenesis). This biosimilar antibody is designed to mimic the activity of the original anti-BIT monoclonal antibody (mAb) in terms of structure, function, and application. In this article, we will discuss the structure, activity, and potential applications of Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade.

Structure

Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade is a recombinant monoclonal antibody that is produced in a mammalian expression system. It is composed of two heavy chains and two light chains, each consisting of variable and constant regions. The variable regions of the antibody are responsible for binding to the target protein, BIT, while the constant regions provide stability and effector functions.

The amino acid sequence of Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade is highly similar to the original anti-BIT mAb, ensuring its ability to bind to the same epitope on the BIT protein. This similarity also makes it a suitable replacement for the original antibody, with minimal risk of immunogenicity or adverse reactions.

Activity

Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade has been shown to exhibit similar activity to the original anti-BIT mAb in various in vitro and in vivo studies. It binds to the BIT protein with high affinity, inhibiting its interaction with its receptor and thereby blocking its downstream signaling pathways.

This inhibition of BIT activity has been shown to have anti-tumorigenic effects, making Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade a potential therapeutic agent for various cancers. It has also been shown to have anti-inflammatory properties, making it a promising candidate for the treatment of autoimmune diseases.

Applications

The primary application of Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade is in the treatment of cancers and autoimmune diseases. Its ability to inhibit BIT activity makes it a potential therapeutic agent for a wide range of cancers, including breast, lung, and colon cancer. It can also be used to treat autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.

In addition to its potential as a therapeutic agent, Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade can also be used as a research tool in various studies related to the BIT protein. Its high specificity and affinity for BIT make it a valuable tool for studying the role of this protein in various disease processes.

Conclusion

Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade is a biosimilar antibody that targets the therapeutic protein BIT. Its structure and activity closely resemble that of the original anti-BIT mAb, making it a suitable replacement for this antibody. With its potential applications in cancer and autoimmune disease treatment, as well as its use as a research tool, Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade shows great promise in the field of biopharmaceuticals.

ProteoGenix catalogue number PX-TA2044. For research use only.

Target: Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade; Clonality: Monoclonal Antibody; Expression system: XtenCHO; Purity: >90% by SDS-PAGE.; Buffer: 0.01M PBS, pH 7.4.; Applications: ELISA, WB.

Available configurations: 50ug, 100ug, 1mg.

Download the manufacturer datasheet

Key facts & specifications
Also known as
anti-BIT, Signal-regulatory protein alpha-1, Brain Ig-like molecule with tyrosine-based activation motifs, MFR, SIRP, Sirp-alpha-1, Sirp-alpha-2, PTPNS1, SIRPA, SHP substrate 1, CD172 antigen-like family member A, Sirp-alpha-3, Inhibitory receptor SHPS-1, Signal-regulatory protein alpha-3, CD172a, Tyrosine-protein phosphatase non-receptor type substrate 1, MyD-1 antigen, Bit, SHPS-1, Macrophage fusion receptor, Signal-regulatory protein alpha-2, SHPS1, MYD1, p84
Clonality
Monoclonal
Isotype
IgG1-kappa
Source organism
Human
Sequence
MEPAGPAPGRLGPLLCLLLAASCAWSGVAGEEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAAENTGSNERNIYIVVGVVCTLLVALLMAALYLVRIRQKKAQGSTSSTRLHEPEKNAREITQDTNDITYADLNLPKGKKPAPQAAEPNNHTEYASIQTSPQPASEDTLTYADLDMVHLNRTPKQPAPKPEPSFSEYASVQVPRK
Technical note
For research use only. Not suitable for clinical or therapeutic use.
Validation & performance evidence
ABMIUM Validated™ ABMIUM Verified™ Expected performance Not suitable

Application validation

Evidence status by application and model.

TargetWBIHC-PIHC-FrIF/ICCFlow CytIPChIPELISA
Anzurstobart Biosimilar – Anti-BIT mAb – Research Grade
Identifiers & database references
Manufacturer SKU
PX-TA2044
UniProt accession
P78324
Storage, stability & shipping
Storage conditions
4°C for short term; -20°C for long term
Shipped at
Blue ice (+4°C)
Compliance & documents
ISO certifications
ISO 9001:2023, ISO 14001: 2023
Datasheet
Open datasheet
Frequently asked questions
Who manufactured this product?

This product is manufactured by ProteoGenix and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

ProteoGenix
£155.00£124.00