ACTR-IIA rabbit pAb from ELK Biotechnology
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ACTR-IIA rabbit pAb is a research-use antibody from ELK Biotechnology for studying ACTR-IIA in WB, ELISA workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013],
| Specificity | ACTR-IIA Polyclonal Antibody detects endogenous levels of ACTR-IIA protein. |
|---|---|
| Validation evidence captions | Western blot analysis of lysates from rat kidney, using ACTR-IIA antibody. |
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Activin A receptor type 2A (ACVR2A) encodes activin receptor type-2A, a transmembrane serine/threonine kinase receptor of the TGF-beta superfamily signalling system. Human ACVR2A maps to NCBI Gene 92 and reviewed UniProtKB P27037; this record links the verified target to related ABMIUM catalogue products.
Biological function: ACVR2A is a type II activin receptor with an extracellular ligand-binding domain and intracellular serine/threonine kinase domain. After ligand binding it forms receptor complexes with type I receptors; the type II receptor phosphorylates and activates type I receptors, which then propagate signalling through SMAD transcriptional regulators. Reviewed UniProt identifies activin A, activin B and inhibin A among its ligands.
