ATG5 Rabbit pAb from ELK Biotechnology
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ATG5 Rabbit pAb is a research-use antibody from ELK Biotechnology for studying ATG5 in IHC workflows with listed reactivity for Human, Mouse, Rat. Specifications and supporting documents below should be reviewed when planning the experiment.
Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10.
| Validation evidence captions | Immunohistochemical analysis of paraffin-embedded Human Hepatocarcinoma Tissue using ATG5 （EA350）Rabbit pAb diluted at 1:200 | Immunohistochemical analysis of paraffin-embedded Human Ovarian Carcinoma Tissue using ATG5 （EA350）Rabbit pAb diluted at 1:200. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Human | |||||||
| Mouse | |||||||
| Rat |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
ATG5 (autophagy related 5), also known as autophagy protein 5, is a core autophagy factor that forms a covalent conjugate with ATG12 and supports ATG8-family lipidation and autophagosome assembly.
Biological function: ATG5 is covalently conjugated to ATG12 through an autophagy-specific ubiquitin-like conjugation pathway. The ATG12-ATG5 complex, together with ATG16L1, provides ATG8-family ligase activity that promotes LC3/GABARAP lipidation on forming autophagosomal membranes and is required for efficient autophagosome assembly.
