P53 Rabbit pAb from ELK Biotechnology
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P53 Rabbit pAb is a research-use antibody from ELK Biotechnology for studying P53 in WB, IHC workflows with listed reactivity for Rat, Mouse. Specifications and supporting documents below should be reviewed when planning the experiment.
p53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro.
| Validation evidence captions | Western blot analysis of 1) Mouse Brain Tissue, 2)Rat Brain Tissue with p53 Rabbit pAb EA173 diluted at 1:2,000. | Immunohistochemical analysis of paraffin-embedded Mouse Colon Tissue using p53（EA173）Rabbit pAb diluted at 1:500. |
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Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Species | WB | IHC | IF | ELISA | IP | FCM | ChIP |
|---|---|---|---|---|---|---|---|
| Rat | |||||||
| Mouse |
This product is manufactured by ELK Biotechnology and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
TP53 identifies tumor protein p53 in Homo sapiens (Human). This target record connects NCBI Gene 7157, UniProtKB P04637 and related ABMIUM catalogue products.
Biological function: TP53 encodes p53, a multifunctional DNA-binding transcription factor that responds to cellular stress by regulating programmes including cell-cycle arrest, DNA repair and apoptosis. Its activity is controlled by extensive protein interactions and post-translational regulation.
