Human Sentrin-specific Protease 1, SENP1 ELISA Kit
Know who made it. See the evidence. Buy through one marketplace.
Protease that catalyzes two essential functions in the SUMO pathway (PubMed: 10652325, PubMed: 15199155, PubMed: 16253240, PubMed: 16553580, PubMed: 21829689, PubMed: 21965678, PubMed: 23160374, PubMed: 24943844, PubMed: 25406032, PubMed: 29506078). The first is the hydrolysis of an alpha-linked Peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked Peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed: 16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed: 21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed: 23160374). Deconjugates SUMO2 from MTA1 (PubMed: 21965678). Deconjugates SUMO1 from METTL3 (PubMed: 29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed: 25406032). Deconjugates SUMO1 from GPS2 (PubMed: 24943844).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
