Human Cytochrome P450 2B6, CYP2B6 ELISA Kit
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A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed: 21289075, PubMed: 12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed: 21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed: 21289075, PubMed: 12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed: 11695850, PubMed: 22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed: 11695850). Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
