Human Aryl Hydrocarbon Receptor Nuclear Translocator, ARNT ELISA Kit
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Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Aryl hydrocarbon receptor nuclear translocator (ARNT; HIF-1β/HIF1B) is a bHLH-PAS transcriptional partner that links AHR xenobiotic signalling with HIF hypoxia responses. This catalogue-backed ABMIUM record links human ARNT (NCBI Gene 405; UniProt P27540) to research reagents.
Biological function: ARNT forms obligate heterodimers with other bHLH-PAS transcription factors. With ligand-activated AHR it supports xenobiotic-response-element transcription, while heterodimerisation with HIF alpha subunits enables hypoxia-response-element transcription controlling adaptive programmes such as angiogenesis, erythropoiesis and metabolic responses.
