Mouse Receptor Tyrosine-protein Kinase ERBB-3, ERBB3 ELISA Kit
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Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
|---|---|---|---|---|---|
| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Erb-b2 receptor tyrosine kinase 3 (ERBB3), also known as HER3, is an EGFR-family receptor that forms signalling heterodimers with other ERBB receptors. ABMIUM catalogue products linked below support research on ERBB3/HER3 biology.
Biological function: Erb-b2 receptor tyrosine kinase 3 (ERBB3/HER3) is an EGFR-family transmembrane receptor with impaired intrinsic kinase activity that signals through heterodimerisation with other ERBB receptors. Ligands including neuregulins promote receptor complex formation and downstream pathways such as PI3K-AKT, supporting cell growth, survival and differentiation.
