Human Neuropilin-1, NRP1 ELISA Kit
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Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed: 9288753, PubMed: 9529250, PubMed: 10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed: 19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed: 9288753, PubMed: 9529250, PubMed: 10688880, PubMed: 19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed: 30623799). [Isoform 2]: Binds VEGF-165 and may inhibit its binding to cells (PubMed: 10748121, PubMed: 26503042). May induce apoptosis by sequestering VEGF-165 (PubMed: 10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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NRP1 identifies neuropilin 1 in Homo sapiens (Human). This target record connects NCBI Gene 8829, UniProtKB O14786 and related ABMIUM catalogue products.
Biological function: Neuropilin 1 (NRP1; neuropilin-1, CD304/BDCA4) is a transmembrane co-receptor that binds vascular endothelial growth factor and semaphorin-family ligands and modulates signalling involved in cell migration, survival, axon guidance and vascular development.
