Human Bone Morphogenetic Protein Receptor 1A, BMPR-1A ELISA Kit
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On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | Serum | Plasma | Cell culture supernatants | Ascites | Tissue homogenates |
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| Compatibility |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
BMPR1A (bone morphogenetic protein receptor type 1A; ALK3/ALK-3, BMPR-1A and CD292) is a type I transmembrane serine/threonine kinase receptor in bone morphogenetic protein signalling. It forms ligand-induced complexes with type II BMP receptors to transmit TGF-beta-superfamily signals through SMAD transcriptional regulators.
Biological function: BMPR1A is a receptor serine/threonine kinase for BMP-family ligands including BMP2, BMP4, GDF5 and GDF6. After ligand binding, type II receptors phosphorylate and activate BMPR1A; the activated type I receptor then engages and activates SMAD transcriptional regulators. This receptor architecture links extracellular BMP cues to transcriptional programmes controlling processes such as differentiation and tissue patterning.
