DTL Polyclonal Antibody
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developmental stage:Expressed in all fetal tissues examined, included brain, lung, liver, and kidney.,Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the WD repeat cdt2 family.,Contains 7 WD repeats.,subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.,subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1.,tissue specificity:Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.,
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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