Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody
Know who made it. See the evidence. Buy through one marketplace.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.|mass spectrometry:Monoisotopic| not modified PubMed:16457589|PTM:Acetylated on Lys-5| Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.|PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|PTM:Not phosphorylated.|Belongs to the histone H2A family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.|
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | ELISA |
|---|---|---|
| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
