Alpha-SMA Polyclonal Antibody
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The product (actin, alpha 1, skeletal muscle) encoded by ACTA1 belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in ACTA1 cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Evidence | WB | IHC-p | ELISA |
|---|---|---|---|
| Applications |
This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Actin alpha 1, skeletal muscle (ACTA1) encodes the skeletal-muscle alpha-actin protein, also named actin, alpha skeletal muscle and alpha-actin-1. Human ACTA1 maps to NCBI Gene 58 and reviewed UniProtKB P68133; this target record links the verified target to related ABMIUM catalogue products.
Biological function: ACTA1 is an alpha-actin isoform of skeletal muscle and a major constituent of the contractile apparatus. Actins are highly conserved proteins involved in cell structure and motility; reviewed UniProt additionally associates ACTA1 with muscle contraction, skeletal-muscle fibre development and thin-filament assembly.
