EMAP II Polyclonal Antibody
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The aminoacyl tRNA synthetase complex interacting multifunctional protein 1 encoded by AIMP1 is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
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This product is manufactured by BT LAB and sold through ABMIUM without relabelling.
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Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1; p43/EMAPII) is a multisynthetase-complex protein studied in tRNA handling, signalling and extracellular cytokine-like biology.
Biological function: AIMP1 is a non-catalytic component of the cytoplasmic multisynthetase complex that binds tRNA and supports aminoacyl-tRNA synthetase activity. Reviewed UniProt also describes signalling functions, including inflammatory cytokine activity and regulation of TGF-beta signalling through SMURF2 stabilization.
