Human ACO1 (Aconitase 1) CLIA Kit with collaborator-tested sample matrix evidence from Elabscience.
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Human ACO1 (Aconitase 1) CLIA Kit from Elabscience is intended for research workflows involving ACO1. Review the listed specifications and supporting documents to confirm compatibility with the intended method.
This product is manufactured by Elabscience and sold through ABMIUM without relabelling.
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Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
Aconitase 1 (ACO1), also known as cytoplasmic aconitate hydratase and iron regulatory protein 1 (IRP1), is a bifunctional human protein linking citrate metabolism with iron-responsive post-transcriptional regulation.
Biological function: ACO1 is a bifunctional cytosolic protein. When assembled with a [4Fe-4S] cluster it acts as aconitase, catalysing the reversible interconversion of citrate and isocitrate through cis-aconitate. Under iron-limiting conditions, loss of the cluster enables ACO1/IRP1 to bind iron-responsive elements in target mRNAs and regulate proteins involved in cellular iron uptake, storage and use.
