ABMIUM target intelligence
autophagy related 4B cysteine peptidase
ATG4B (autophagy related 4B cysteine peptidase), also called cysteine protease ATG4B or autophagin-1, is an ATG4-family cysteine protease central to ATG8-family protein processing during macroautophagy.
Read full target overview![Anti-Human/Mouse ATG4B Antibody [A343] - ABMIUM](http://www.abmium.com/cdn/shop/files/gSKB2e6W.jpg?v=1781566863&width=520)
![Anti-Human/Rat/Mouse ATG4B Antibody [A447] - ABMIUM](http://www.abmium.com/cdn/shop/files/2EqFOD8o.jpg?v=1781567063&width=520)
Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
ATG4B is a peptidase family C54 cysteine protease that processes ATG8-family proteins, including LC3 and GABARAP family members, to expose the C-terminal glycine required for lipidation. It also removes lipid modifications from ATG8-family proteins, regulating autophagosome membrane dynamics and autophagic flux.
ATG4B is widely studied in macroautophagy because ATG8-family processing and delipidation influence LC3/GABARAP membrane association, autophagosome maturation and flux. Protease-activity, lipidation and autophagic-flux assays should be interpreted in the context of substrate specificity and other ATG4-family enzymes.
Names used across publications, databases and supplier catalogues.
