ABMIUM target intelligence
APC regulator of Wnt signaling pathway
APC (APC regulator of Wnt signaling pathway; adenomatous polyposis coli protein) is a multifunctional tumour-suppressor scaffold best known for restraining canonical Wnt signalling by promoting beta-catenin turnover.
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Names used across publications, databases and supplier catalogues.
APC is a core component of the beta-catenin destruction machinery and promotes CTNNB1/beta-catenin degradation when canonical Wnt signalling is inactive. APC also associates with cytoskeletal systems, contributing to cell polarity, migration and cellular organisation.
APC is widely studied in Wnt/beta-catenin signalling, epithelial homeostasis, cell polarity and Wnt-driven tumour biology. Use ABMIUM APC-associated products only after confirming the intended species, sample type, assay format, application and product-level validation.