ABMIUM target intelligence
AKT1 substrate 1
AKT1S1 (AKT1 substrate 1; PRAS40) encodes proline-rich AKT1 substrate 1, a phosphorylation-sensitive regulator of mechanistic target of rapamycin complex 1 (mTORC1).
Read full target overview![Anti-Human/Mouse/Rat PRAS40 Antibody [B845] - ABMIUM](http://www.abmium.com/cdn/shop/files/EebnrVEI.jpg?v=1781565348&width=520)
![Anti-Human/Mouse/Rat PRAS40 Antibody [B1101] - ABMIUM](http://www.abmium.com/cdn/shop/files/d0GxzZSM.jpg?v=1781566122&width=520)
![Anti-Human/Rat/Mouse PRAS40 Antibody [A589] - ABMIUM](http://www.abmium.com/cdn/shop/files/0iydKkmN.jpg?v=1781567389&width=520)
Research context & evidence
Target information is kept separate from product-level validation so you can review the biology and the reagent evidence independently.
PRAS40/AKT1S1 negatively regulates mTORC1 by associating with the complex and limiting substrate access under low insulin or nutrient conditions. Insulin- and nutrient-responsive phosphorylation promotes 14-3-3 binding and relief of mTORC1 inhibition.
AKT1S1/PRAS40 is studied at the intersection of AKT signalling, nutrient sensing, mTORC1 control, cell growth and metabolic regulation. Catalogue-backed reagents should be selected using product-specific species and application validation.
Names used across publications, databases and supplier catalogues.
