ABMIUM target intelligence
absent in melanoma 2
AIM2 is absent in melanoma 2, also known as interferon-inducible protein AIM2. It is a cytosolic double-stranded DNA sensor and core component of the AIM2 inflammasome, linking detection of misplaced DNA to innate inflammatory responses.
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Names used across publications, databases and supplier catalogues.
AIM2 binds cytosolic double-stranded DNA through its HIN domain and assembles an inflammasome with the adaptor ASC, enabling caspase-1 activation. This promotes maturation of inflammatory cytokines and gasdermin-dependent pyroptotic cell death as part of innate defence against cytosolic DNA.
AIM2 is studied in innate immunity, inflammasome activation, host defence, sterile inflammation and cell-death biology. Experimental interpretation should distinguish AIM2 expression from actual inflammasome assembly and activation, which also depends on cytosolic DNA and downstream components. Reagent choice should be matched to species, sample type, assay format and product-level validation.