ELISA Kit von Boster Bio
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Komplementkomponente 3, oft einfach C3 genannt, ist ein Protein des Immunsystems. Beim Menschen wird es auf Chromosom 19 durch ein Gen namens C3 kodiert. Komplementkomponente C3 spielt eine zentrale Rolle bei der Aktivierung des Komplementsystems. Ihre Aktivierung ist sowohl für den klassischen als auch für den alternativen Komplementaktivierungsweg erforderlich. Das kodierte Präproprotein wird proteolytisch prozessiert, um Alpha- und Beta-Untereinheiten zu erzeugen, die das reife Protein bilden, welches dann weiterverarbeitet wird, um zahlreiche Peptidprodukte zu erzeugen. Das C3a-Peptid, auch bekannt als C3a-Anaphylatoxin, moduliert Entzündungen und besitzt antimikrobielle Aktivität. Mutationen in diesem Gen sind beim Menschen mit atypischem hämolytisch-urämischem Syndrom und altersbedingter Makuladegeneration assoziiert.
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Probenkompatibilität | Assay-Bereich | Empfindlichkeit | Spezifität |
|---|---|---|---|---|
| Zellkulturüberstände | ||||
| Serum | ||||
| Plasma (Heparin | ||||
| EDTA | ||||
| Citrat) und Urin |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.
Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.
Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.
C3 (complement C3) is the central complement precursor cleaved into C3a and C3b, linking complement activation to inflammatory signalling, opsonization and downstream C5 activation.
Biological function: Complement C3 is activated by C3 convertases across the classical, lectin and alternative pathways. Cleavage generates C3a, an anaphylatoxin involved in inflammatory signalling, and C3b, which covalently labels surfaces for opsonization, supports complement amplification and contributes to C5 convertase formation. Additional processing generates iC3b and other fragments with distinct immune functions.
