Primärantikörper geliefert von Boster Bio
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Alpha-Methylacyl-CoA-Racemase (AMACR) ist ein mitochondriales und peroxisomales Enzym. Es kodiert eine Racemase. Das kodierte Enzym wandelt Pristanoyl-CoA und C27-Gallensäure-CoA zwischen ihren (R)- und (S)-Stereoisomeren um. Die Umwandlung in die (S)-Stereoisomere ist für den Abbau dieser Substrate durch peroxisomale Beta-Oxidation notwendig. Die an diesem Locus kodierten Proteine lokalisieren sowohl in Mitochondrien als auch in Peroxisomen. Mutationen in diesem Gen können mit einer spät einsetzenden sensomotorischen Neuropathie, Pigmentretinopathie und Adrenomyeloneuropathie aufgrund von Defekten in der Gallensäuresynthese assoziiert sein. Es wurden alternativ gespleißte Transkriptvarianten beschrieben. Es existiert auch eine Read-through-Transkription zwischen diesem Gen und dem stromaufwärts gelegenen Nachbargen C1QTNF3 (C1q- und Tumornekrosefaktor-bezogenes Protein 3).
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Evidence status by application and model.
| Arten | WB | IHC | IHC-P | IHC-F | IF/ICC | Durchflusszytometrie | ELISA | IP |
|---|---|---|---|---|---|---|---|---|
| Human | ||||||||
| Maus | ||||||||
| Ratte |
This product is manufactured by Boster Bio and sold through ABMIUM without relabelling.
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AMACR (alpha-methylacyl-CoA racemase; P504S) is a mitochondrial and peroxisomal enzyme that interconverts stereoisomers of alpha-methyl branched acyl-CoA substrates. It is studied in branched-chain fatty-acid oxidation, bile-acid intermediate metabolism and metabolic enzyme expression research.
Biological function: Alpha-methylacyl-CoA racemase converts (2R)-2-methylacyl-CoA esters to the (2S) configuration required for downstream beta-oxidation. Human AMACR acts on substrates derived from branched-chain fatty acids such as pristanic acid and on bile-acid synthesis intermediates, linking peroxisomal and mitochondrial lipid metabolism.
