YM-58483 is a CRAC (calcium release-activated calcium) channel blocker, a prototypic store-operated calcium channel. Inhibits antigen-induced histamine release via modulation of mast cell responses. Displays potent analgesic actions in various pain models in mice and is orally active. Inhibits T...
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YM-58483 is a CRAC (calcium release-activated calcium) channel blocker, a prototypic store-operated calcium channel. Inhibits antigen-induced histamine release via modulation of mast cell responses. Displays potent analgesic actions in various pain models in mice and is orally active. Inhibits T cell-mediated immune responses in vivo
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