A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis. Blocks Jak2 signaling via Jak2 ubiquitination. Causes ablation of the oncogenic transcription factor ERG in prostate cancer cells
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A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis. Blocks Jak2 signaling via Jak2 ubiquitination. Causes ablation of the oncogenic transcription factor ERG in prostate cancer cells
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